Water sample analysis:
- Arsenic concentration
- Copper concentration
- Zinc & Nickel concentration
- Cadmium levels
- Total protein concentration
- RNA/DNA concentration
- Designated spectrophotometric
- Energy Sciences
- Pollution dynamics
- Water pollution circulation
- Life cycle of pollutants
- Heavy Metals
- Molecular interactions
- Environmental remediation
- Waste management
- Exotic Materials
NANOGEL: Biodegradable nanoshuttles as therapeutic agents for cancer treatment
DDS Diagnostic. Dr. D. Stand. Bd-ul Gheorghe Sincai, 9A, sector 4, Bucuresti. Romania.
Project duration: 2016-
Cancer treatments are frequently associated with high costs of synthesis, a series of negative side-effects and administration of the agent through the blood, causing affection of other parts of the system. Conventional therapies include inhibitors of caspases and particularly kinases, however other parts of the proteomic system are of particular interest for cancer research. In a recent study an avenue of importance to treatment has been found, with emphasis on applying in-house synthesized biodegradable nanogels as nanoshuttles for the therapetuic agent. An image of these nanogels is pictures below, which act as transporters of a developed nanoparticle which affects a given pathway of relevance in cancer cells. This project is developed to perform in vitro and in vivo tests of the materials towards PC3, PC93, MFC7 and T47D cells in cell culture systems and aims to prepare a formular of the nanogels+nanoparticles for treatment of cancer.
Keywords: Nanoparticles, nanogels, cancer, treatment, in vitro, in vivo, apoptosis.
Project participants: Manzetti S. and Stan D.
Fig. 1. High-resolution image of microparticles (5-10um) of biodegradable nanogels containing therapeutic agents for cancer treatment.
Fig. 2. Normalized proliferation values of NANOGEL microemulsions against B16-F10 cancer cell lines. Cell-density: 5000 cells/well. Labels: 1: Undiluted NANOGEL suspension; 0.5: 1:2 dilution; 0.25: 1:4 dilution; 0.125: 1:8 dilution and 0.0625: 1:16 dilution of NANGEL in medium. Peak cell-death effects at medium-concentrations, within 48hrs.
Fig. 3. Normalized proliferation values of NANOGEL microemulsions against B16-F10 cancer cell lines. Cell-density: 10000 cells/well. Labels: 1: Undiluted NANOGEL suspension; 0.5: 1:2 dilution; 0.25: 1:4 dilution; 0.125: 1:8 dilution and 0.0625: 1:16 dilution of NANGEL in medium. Peak cell-death effects at medium-concentrations, within 48hrs.
NANOGEL is projected to be a low-cost alternative to high-cost treatments for cancer. The technology is under development by the partners DDS and Fjordforsk A/S. For investment inquiries please contact the project leader, Manzetti.
Fjordforsk is a member of the American Chemical Society. Please visit the society following the logo below.
27 Okt.: Review on biochemical effects from exhaust emissions published in Pathophysiology. Read more
8th Sept.: New study on the binding of pollutants to human proteins published at the American Chemical Society. Read more
20 Jun.: New article on the process of nanoparticle-formation in bioethanol fuel blends. A computational study published in Fuel. Read more