Content on this page requires a newer version of Adobe Flash Player.

Get Adobe Flash player

Services

 

Water sample analysis:

- Arsenic concentration
- Copper concentration
- Zinc & Nickel concentration
- Cadmium levels

Biological samples:

- Total protein concentration
- RNA/DNA concentration
- Designated spectrophotometric
tests

Research Areas

- Toxicology
- Energy Sciences
- Pollution dynamics
- Water pollution circulation
- Life cycle of pollutants
- Heavy Metals
- Molecular interactions
- Environmental remediation
- Waste management
- Exotic Materials

 

 

Fjordforsk A.S. Midtun, 6894 Vangsnes, Norway.
Org.nr: 911659654 | www.fjordforsk.no

NANOGEL: Biodegradable nanoshuttles as therapeutic agents for cancer treatment

 

Collaborating Institute:

DDS Diagnostic. Dr. D. Stand. Bd-ul Gheorghe Sincai, 9A, sector 4, Bucuresti. Romania.

Funding agency:

Project duration: 2016-

Project description:

Cancer treatments are frequently associated with high costs of synthesis, a series of negative side-effects and administration of the agent through the blood, causing affection of other parts of the system. Conventional therapies include inhibitors of caspases and particularly kinases, however other parts of the proteomic system are of particular interest for cancer research. In a recent study an avenue of importance to treatment has been found, with emphasis on applying in-house synthesized biodegradable nanogels as nanoshuttles for the therapetuic agent. An image of these nanogels is pictures below, which act as transporters of a developed nanoparticle which affects a given pathway of relevance in cancer cells. This project is developed to perform in vitro and in vivo tests of the materials towards PC3, PC93, MFC7 and T47D cells in cell culture systems and aims to prepare a formular of the nanogels+nanoparticles for treatment of cancer.


Keywords: Nanoparticles, nanogels, cancer, treatment, in vitro, in vivo, apoptosis.


Project participants: Manzetti S. and Stan D.

Publications:

Manzetti S, Tzamneti O. (2013). Hypoxia-induced signaling and its relevance in discovering biomarkers for cancer research. Biomarkers and Genomic Medicine, 5:135-141.

 

Fig. 1. High-resolution image of microparticles (5-10um) of biodegradable nanogels containing therapeutic agents for cancer treatment.

 

Fig. 2. Normalized proliferation values of NANOGEL microemulsions against B16-F10 cancer cell lines. Cell-density: 5000 cells/well. Labels: 1: Undiluted NANOGEL suspension; 0.5: 1:2 dilution; 0.25: 1:4 dilution; 0.125: 1:8 dilution and 0.0625: 1:16 dilution of NANGEL in medium. Peak cell-death effects at medium-concentrations, within 48hrs.

 

Fig. 3. Normalized proliferation values of NANOGEL microemulsions against B16-F10 cancer cell lines. Cell-density: 10000 cells/well. Labels: 1: Undiluted NANOGEL suspension; 0.5: 1:2 dilution; 0.25: 1:4 dilution; 0.125: 1:8 dilution and 0.0625: 1:16 dilution of NANGEL in medium. Peak cell-death effects at medium-concentrations, within 48hrs.

 

NANOGEL is projected to be a low-cost alternative to high-cost treatments for cancer. The technology is under development by the partners DDS and Fjordforsk A/S. For investment inquiries please contact the project leader, Manzetti.

 


 

Fjordforsk is a member of the American Chemical Society. Please visit the society following the logo below.

 

 

News

 

27 Okt.: Review on biochemical effects from exhaust emissions published in Pathophysiology. Read more

8th Sept.: New study on the binding of pollutants to human proteins published at the American Chemical Society. Read more

20 Jun.: New article on the process of nanoparticle-formation in bioethanol fuel blends. A computational study published in Fuel. Read more

Home | Collaborations | Publications | Projects | Contact | Services

Content on this page requires a newer version of Adobe Flash Player.

Get Adobe Flash player